In the field of regenerative medicine, PRGF-Endoret (Plasma Rich in Growth Factors) technology is an advanced treatment modality that accelerates tissue repair and renewal by utilising growth factors derived from the patient's own blood. Considered a more refined and controlled version of PRP therapy, PRGF ranks among the most prominent applications in medical aesthetics in 2026.
What Is PRGF-Endoret?
PRGF is an autologous plasma preparation developed by Spanish scientist Dr Eduardo Anitua and standardised through Endoret technology. Obtained from the patient's own venous blood via a specialised centrifuge protocol, this preparation contains a high concentration of growth factors.
Its most important distinction from conventional PRP is that it contains no leukocytes (white blood cells). Because leukocytes can secrete inflammatory cytokines, PRGF's leukocyte-free composition delivers a more controlled, anti-inflammatory response during tissue healing.
Differences Between PRP and PRGF
Although both treatments use autologous blood products, there are significant differences between them:
- Leukocyte content: PRGF contains no leukocytes, whereas most standard PRP preparations do.
- Activation method: PRGF is activated in a controlled manner with calcium chloride, enabling a more regulated release of growth factors.
- Standardisation: The Endoret technology ensures an extremely standardised and reproducible preparation protocol.
- Fibrin membrane formation: Biologically active fibrin membranes can be obtained from PRGF; these membranes are used in surgical applications and wound healing.
Applications in Medical Aesthetics
PRGF-Endoret treatment has a broad application spectrum in the aesthetic field:
Skin Renewal and Anti-Ageing
Growth factors injected into the dermal layer of the skin stimulate collagen and elastin synthesis. Firming of skin tissue, reduction of fine lines, and an overall improvement in radiance are observed. Particularly effective results are achieved in the eye contour, neck, and décolletage areas.
Hair Loss Treatment
In hair loss conditions such as androgenetic alopecia and telogen effluvium, PRGF applied to hair follicles supports the transition of follicles into the growth (anagen) phase. Measurable increases in hair thickness and density have been confirmed by clinical studies.
Wound Healing and Scar Treatment
The tissue-regeneration-accelerating effect of PRGF is utilised in the treatment of acne scars, surgical scars, and post-burn scar tissue.
Treatment Protocol
The treatment process consists of the following steps:
- Approximately 20–40 ml of venous blood is collected from the patient.
- The blood samples are processed in a dedicated Endoret centrifuge device.
- Leukocyte-free, growth-factor-rich plasma fractions are separated.
- Activation is performed with calcium chloride.
- The prepared preparation is injected into the target area.
Treatment programmes consisting of 3–4 sessions at 2–4 week intervals are generally recommended. As a maintenance regimen, sessions may be repeated 1–2 times per year.
Safety and Advantages
Because PRGF is derived from the patient's own blood, there is no risk of allergic reaction or incompatibility. As it contains no leukocytes, post-procedural swelling and redness are less pronounced compared to conventional PRP. A rapid return to social activities is possible following the procedure.
As of 2026, PRGF-Endoret stands out as a treatment option that has proven its reliability and efficacy among evidence-based regenerative aesthetic applications. Please contact Virtuana Clinic for a personalised assessment.
This article is for informational purposes only. Please consult a qualified physician for treatment decisions.