PRP (Platelet-Rich Plasma) therapy has been used successfully in medical aesthetics for many years. As of 2026, however, its evolved counterpart — PRF (Platelet-Rich Fibrin) — is attracting attention for its superior outcomes. So what exactly is PRF, how does it differ from PRP, and what role does it play in skin rejuvenation?
What Is PRF?
PRF is a fibrin matrix derived from the patient's own blood that is rich in platelets and leukocytes. Its most fundamental distinction from PRP is that no anticoagulants or additives are used during preparation. After blood is drawn, it is processed using a specialised centrifuge protocol, yielding a completely natural biomaterial.
The fibrin matrix traps growth factors within its structure, enabling a slow, controlled release. As a result, the duration of effect is considerably longer compared to PRP.
Differences Between PRF and PRP
| Feature | PRP | PRF |
|---|---|---|
| Additives | Anticoagulant added | Completely natural, additive-free |
| Growth-factor release | Rapid and short-lived | Slow, spread over 10–14 days |
| Leukocyte content | Low | High |
| Fibrin structure | Liquid plasma | Three-dimensional fibrin network |
| Tissue integration | Absorbed quickly | Remains in tissue longer |
| Preparation time | Standard | Time-sensitive (rapid processing required) |
Applications of PRF in Medical Aesthetics
Skin Rejuvenation
PRF injections powerfully stimulate collagen and elastin production in the skin. Thanks to the slow-release properties of the fibrin matrix, a regenerative process begins that continues for weeks after treatment. Noticeable improvements are observed in fine lines, enlarged pores, and uneven skin tone.
Under-Eye and Dark Circle Treatment
The under-eye area is one of the zones where PRF is most effective. Dark circles and volume loss that develop in this region due to thin skin and high vascular density can be treated naturally with PRF.
Hair Loss Treatment
By nourishing hair follicles and activating dormant ones, PRF delivers longer-lasting results than PRP in the treatment of androgenetic alopecia.
Wound Healing and Scar Treatment
In acne scarring and post-surgical wound healing, PRF contributes to faster, higher-quality tissue repair.
How Does the PRF Treatment Process Work?
- Blood draw: 1–4 tubes of venous blood are collected from the patient.
- Centrifugation: The blood is centrifuged using a specialised protocol; timing is critical because no anticoagulant is used.
- PRF extraction: The resulting fibrin layer is separated and prepared for injection.
- Application: Administered to the target area via micro-injections or in combination with microneedling.
- Recovery: Mild redness and swelling subside within 24–48 hours.
Three to four sessions are generally recommended, with 3–4 weeks between sessions. Results emerge gradually from the first session and may last 6–12 months.
Advantages of PRF Therapy
- 100% natural: Contains no chemical additives.
- No risk of allergic reaction: Derived entirely from the patient's own blood.
- Long-lasting effect: Owing to the slow-release mechanism.
- Minimal side effects: No significant side effects are expected beyond mild swelling and bruising.
PRF Treatment at Virtuana Clinic
At Virtuana Clinic, PRF therapy is administered using the latest centrifuge protocols and under fully sterile conditions. To benefit from the wide range of advantages PRF offers — from skin rejuvenation to hair restoration — please contact us for a personalised consultation.
This article is for informational purposes only. Please consult a qualified physician for treatment decisions.