Ozone treatment is a method based on the therapeutic use of medical ozone gas under controlled conditions. This approach, which is attracting increasing interest in dermatology and aesthetics, continues to be at the centre of scientific debate in 2026.
What Is Medical Ozone?
Medical ozone is a molecule composed of three oxygen atoms, produced under controlled conditions by medical ozone generators. In dermatological applications it is generally used as an oxygen-ozone mixture. Concentration and route of administration are determined according to the condition being treated.
Mechanisms of Action on the Skin
The effects of ozone therapy on the skin are multifaceted:
Antimicrobial Effect: As a powerful oxidant, ozone is effective against bacteria, viruses, and fungi. This property is being evaluated particularly in the management of acne, wound infections, and skin infections.
Oxygen Metabolism: Ozone improves oxygen utilisation in tissues. By increasing 2,3-diphosphoglycerate levels it facilitates oxygen release from haemoglobin, supporting the metabolic activity of skin cells.
Antioxidant Defence: Paradoxically, controlled-dose ozone application stimulates the body's endogenous antioxidant systems. The activity of enzymes such as superoxide dismutase, glutathione peroxidase, and catalase is increased.
Immunomodulation: Ozone may modulate the immune response by regulating cytokine profiles. This effect may offer potential benefit in chronic inflammatory skin diseases.
Dermatological Applications
Chronic Wounds and Ulcers
Chronic wound care is the field in which ozone therapy has the strongest evidence base. Studies exist showing that ozone application as an adjunct to conventional treatment accelerates the healing process in diabetic foot ulcers and venous ulcers.
Acne and Inflammatory Skin Conditions
The antimicrobial and anti-inflammatory properties of ozone are being investigated as an adjunctive approach in acne treatment. Its bactericidal effect on Cutibacterium acnes and its regulatory potential on sebum production are attracting attention.
Skin Rejuvenation
Ozonated olive oil and local ozone applications have been reported to improve skin texture and support collagen synthesis. However, studies in this area are still at a preliminary stage.
Herpes and Viral Infections
Data exist suggesting that topical ozone application shortens the duration of symptoms in herpes simplex and herpes zoster lesions.
Application Methods
The main application methods of ozone therapy in dermatology are as follows:
- Local ozone bagging: The affected area is brought into contact with ozone gas
- Ozonated oils: Ozonated olive oil or sunflower oil is used for topical application
- Minor autohemotherapy: A small amount of blood is drawn, ozonated, and reinjected
- Subcutaneous injection: An oxygen-ozone mixture is injected beneath the skin
Safety and Side Effects
Medical ozone treatment is generally considered safe when carried out under appropriate conditions by trained practitioners. However, because direct inhalation of ozone can cause serious lung damage, the environment and technique of application are of great importance.
Side effects that may occur with local applications include a mild burning sensation, transient erythema, and, rarely, allergic reactions.
2026 Perspective
While the dermatological use of ozone therapy shows promise, the level of evidence is still evolving. More research is needed on standardised protocols, dose optimisation, and long-term safety data. Patients considering this treatment are advised to consult experienced clinicians and to set realistic expectations. Please contact us for pricing information on ozone therapy services at Virtuana Clinic.
This article is for informational purposes only. Please consult a qualified physician for treatment decisions.