Skin Mesotherapy Guide: Skin Renewal from Vitamins to Peptides (2026)

Skin mesotherapy is a minimally invasive medical aesthetic procedure in which special cocktails containing vitamins, hyaluronic acid, amino acids, peptides and minerals are injected with very fine needles into the middle layer of the skin (mesoderm) for the purpose of skin renewal and rejuvenation. At Virtuana Clinic, Dr. Abdülmelik Dönmez applies customised mesotherapy protocols tailored to each patient's skin type in Izmit/Kocaeli. Clinical studies have reported a 60–80% increase in skin hydration, a 165–256% improvement in collagen synthesis and a 82% patient satisfaction rate following mesotherapy application.

What Is Skin Mesotherapy?

Skin mesotherapy is an aesthetic medicine application developed in 1952 by French physician Dr. Michel Pistor, in which active substances are delivered via micro-injections into the middle layer of the skin (mesoderm, 1–4 mm depth). The aim is to achieve skin renewal by delivering active substances directly to the target tissue.

Core Principles of Mesotherapy:

1. Right place: Mesodermal layer (1–4 mm depth)
2. Right time: Every 2–4 weeks according to skin needs
3. Right dose: Minimum effective dose principle
4. Right product: Cocktail selection based on skin type and concern

Parameter	Detail
Injection depth	1–4 mm (intradermal/mesodermal)
Needle gauge	30–32 gauge
Session duration	20–30 minutes
Pain level	Minimal (with topical anaesthetic)
Social recovery	24–48 hours
Number of sessions	4–6 sessions (initial course)

How Is Mesotherapy Applied? Technique Comparison

Mesotherapy application techniques are carried out by three main methods: manual injection (point-by-point), mesotherapy gun (mesogun) and dermapen. Each technique has different advantages, disadvantages and indications.

Application Steps:

1. Skin cleansing: Facial cleansing with antiseptic solution
2. Topical anaesthesia: Anaesthetic cream application (20–30 minutes waiting)
3. Cocktail preparation: Patient-specific formulation
4. Injection: Application using the selected technique
5. Cooling: Cold compress after the procedure
6. Sun protection: SPF 50+ application

Mesotherapy Gun vs Manual Technique Comparison Table:

Criterion	Manual Technique (Point-by-Point)	Mesogun (Gun)	Dermapen/Micro-needling
Depth control	Depends on physician skill	Digitally adjustable (0.5–4 mm)	Digitally adjustable (0.25–3 mm)
Dose accuracy	Variable	±0.01 ml precision	Topical application
Pain level	Moderate	Low–moderate	Low
Application speed	Slow (20–40 min)	Fast (10–15 min)	Moderate (15–25 min)
Product waste	Low	Very low	Variable
Physician experience required	Very high	Moderate	Moderate
Homogeneous distribution	Experience-dependent	Excellent	Good
Cost	Low (equipment)	Moderate–high	Moderate
Best suited area	Around the eye, fine areas	General face	General face, scar treatment

Dermapen vs Mesotherapy Difference:

Parameter	Mesotherapy	Dermapen (Micro-needling)
Active substance delivery	Directly by injection	Diffusion through micro-channels
Depth	1–4 mm (mesodermal)	0.25–3 mm (epidermal–dermal)
Mechanism of action	Pharmacological + mechanical	Mechanical (collagen induction) + topical
Cocktail volume	3–5 ml/session	1–2 ml (topical serum)
Collagen increase	165–256% (NCTF data)	200–400% (mechanical stimulation)
Session interval	2–4 weeks	4–6 weeks
Indication	Skin renewal, hydration	Scars, acne marks, skin texture

Cocktail Ingredient Analysis: In-Depth Active Substance Guide

Mesotherapy cocktails are multi-component formulations targeting skin renewal, and each active substance fulfils a specific biological function. An effective cocktail contains a synergistic combination of hyaluronic acid, vitamins, amino acids, peptides and minerals.

Hyaluronic Acid (HA) Concentrations

Hyaluronic acid is the skin's natural moisturising component and the most widely used active substance in mesotherapy. Different molecular weights of HA have different effects.

HA Type	Molecular Weight	Effect	Penetration Depth
Low MW HA	< 100 kDa	Collagen stimulation, anti-inflammatory	Deep dermis
Medium MW HA	100–500 kDa	Hydration + skin repair	Mid dermis
High MW HA	500–1500 kDa	Surface hydration, moisture barrier	Upper dermis
Cross-linked HA	Variable	Long-term volume + hydration	Variable

Vitamin C Forms

Vitamin C is a powerful antioxidant and a key mesotherapy component acting as a cofactor in collagen synthesis.

Vitamin C Form	Stability	Efficacy	Mesotherapy Suitability
L-Ascorbic acid	Low (sensitive to oxidation)	★★★★★	Freshly prepared cocktails
Sodium ascorbyl phosphate	High	★★★★☆	Ready-made cocktail formulations
Ascorbyl glucoside	Very high	★★★☆☆	Long shelf-life products
Ethyl ascorbic acid	High	★★★★☆	Premium cocktail formulations

Peptide Types

Peptides are short amino acid chains that regulate cellular processes.

Peptide	Amino Acid Count	Function	Clinical Effect
Acetyl hexapeptide-3 (Argireline)	6	Neuromuscular blockade	Botox-like effect (30% line reduction)
Palmitoyl tripeptide-1	3	Collagen I, III, IV synthesis	Wrinkle reduction (25–40%)
Palmitoyl tetrapeptide-7	4	Anti-inflammatory	IL-6 reduction, skin calming
Copper peptide (GHK-Cu)	3	Wound healing, collagen	Skin repair (70% acceleration)
Palmitoyl pentapeptide-4 (Matrixyl)	5	ECM renewal	Wrinkle depth reduction (36%)

Minerals and Trace Elements

Mineral	Function	Deficiency Sign
Zinc (Zn)	Wound healing, sebum regulation	Acne, slow healing
Selenium (Se)	Antioxidant, UV protection	Premature ageing
Silicon (Si)	Collagen synthesis, elasticity	Sagging, elasticity loss
Magnesium (Mg)	Enzyme activation, skin barrier	Dry, sensitive skin
Manganese (Mn)	SOD activation, antioxidant	Oxidative stress

NCTF vs Meso-Xanthin: Detailed Comparison

NCTF (New Cellular Treatment Factor) is a polycomponent biorevitalisation solution containing 53 active components. Meso-Xanthin F199 is a next-generation mesotherapy product based on fucoxanthin, targeting cellular DNA repair. Both products are effective in skin rejuvenation, but their mechanisms of action and indications differ.

NCTF 135HA Content (53 Components):

• 12 vitamins: A, B1, B2, B3, B5, B6, B8, B9, B12, C, E, H
• 23 amino acids: Including all essential amino acids
• 6 minerals: Zn, Mg, Se, Si, Cu, Mn
• 6 coenzymes: CoA, FAD, NAD, NADP, TPP, UTP
• 5 nucleotides: Deoxyribonucleic acid components
• 1 antioxidant: Glutathione
• Hyaluronic acid: At 5 mg/ml concentration

Meso-Xanthin F199 Mechanism of Action:

• Fucoxanthin: Activates DNA repair genes
• Anti-inflammatory: Inhibits chronic inflammation
• Photo-ageing protection: Cellular resistance to UV damage
• Regeneration: Renewal of damaged and aged skin cells

NCTF vs Meso-Xanthin Comparison Table:

Criterion	NCTF 135HA	Meso-Xanthin F199
Number of components	53	Main component: Fucoxanthin
Mechanism of action	Multiple nutrients + biorevitalisation	DNA repair + gene expression
HA content	5 mg/ml	None
Collagen stimulation	165–256% increase	At gene expression level
Indication	General skin rejuvenation	Photo-ageing, chronic damage
Clinical study data	Extensive (multiple RCTs)	Limited (developing evidence base)
Sessions	5 sessions (15 days apart)	4–6 sessions (2–4 weeks apart)
Time to see results	From session 3	From session 4
Price level	Moderate–high	High
Best results	Age 30–50, general renewal	Age 35–55, photo-damage focused

Clinical data have shown that NCTF increases intracellular collagen synthesis in normal fibroblasts by 165% and extracellular collagen synthesis by 200%. In aged fibroblasts these increases were measured as 166% and 256% respectively.

Glogau Photo-Ageing Classification

The Glogau classification is a dermatological assessment system dividing skin photo-ageing into four types, used as a guide in treatment planning. The recommended mesotherapy protocol differs for each type.

Type	Description	Age Range	Clinical Features	Recommended Mesotherapy
Type I	No wrinkles	20–30	Early photo-damage, no spots	Preventive: Vitamin C + HA
Type II	Wrinkles with movement	30–40	Mild photo-damage, early lentigines	NCTF + antioxidant cocktail
Type III	Wrinkles at rest	40–55	Marked photo-damage, keratoses	Intensive NCTF + peptide + growth factor
Type IV	Wrinkles only	55+	Advanced photo-damage, yellow-grey skin	Meso-Xanthin + NCTF + biostimulant

Mesotherapy Session Plan by Glogau Type:

Glogau Type	Initial Course	Maintenance	Combined Treatment Suggestion
Type I	3 sessions (every 3 weeks)	Every 2–3 months	SPF + antioxidant serum
Type II	4–5 sessions (every 2 weeks)	Monthly	Chemical peeling + LED
Type III	6 sessions (every 2 weeks)	Every 3–4 weeks	Laser + PRP + filler
Type IV	6–8 sessions (every 10–15 days)	Every 2–3 weeks	HIFU + biostimulant + laser

Skin Barrier and Mesotherapy

The skin barrier is a physical defence structure in the epidermis composed of a lipid matrix and corneocytes that protects the skin from external factors. Mesotherapy strengthens the skin barrier while simultaneously enabling active substances to cross this barrier and reach the dermal layer.

Skin Barrier Components:

Component	Proportion (%)	Function	Mesotherapy Support
Ceramides	50	Lipid barrier	Ceramide precursors
Cholesterol	25	Structural integrity	Mineral support
Fatty acids	15	Flexibility	Omega-3, Omega-6
Natural moisturising factors (NMF)	10	Hydration	HA + amino acids

Post-Mesotherapy Barrier Healing Process:

1. 0–6 hours: Micro-trauma period (temporary disruption of barrier)
2. 6–24 hours: Acute inflammatory response (growth factor release)
3. 1–3 days: Barrier repair initiation
4. 3–7 days: Acceleration of collagen synthesis
5. 7–14 days: Completion of barrier restoration
6. 2–4 weeks: New collagen and elastin production

Cocktail Types and Indications

Mesotherapy cocktails are ready-made or magistral (physician-prepared) solutions formulated according to the treatment goal, consisting of different combinations of active substances. Each cocktail type targets specific skin concerns.

Cocktail Type	Key Components	Target Concern	Sessions
Brightening	Glutathione + Vitamin C + Tranexamic acid	Pigmentation, uneven tone	6–8 sessions
Anti-ageing	NCTF + Peptides + Growth factors	Wrinkles, elasticity loss	5–6 sessions
Hydration	HA (high + low MW) + B5	Dehydrated skin	4 sessions
Acne	Zinc + Salicylic acid + Niacinamide	Active acne, excess sebum	6–8 sessions
Hair	Biotin + Dexpanthenol + Zinc + Minoxidil	Hair loss	8–12 sessions
Eye area	Peptides + Organic silicon + HA	Dark circles, fine lines	4–6 sessions

Glutathione Mesotherapy: Skin Brightening

Glutathione is a powerful antioxidant tripeptide produced naturally in the body that brightens the skin by regulating melanin synthesis. Glutathione administered via mesotherapy provides 80–90% higher bioavailability compared to topical application.

Glutathione Mesotherapy Protocol:

Parameter	Detail
Concentration	200–600 mg/session
Combined substances	Vitamin C (500 mg), Alpha lipoic acid
Session interval	Weekly (first 6 weeks), then every 2 weeks
Time to see results	After 4–6 sessions
Maintenance	1 session/month

Mesotherapy vs Other Skin Renewal Procedures

Mesotherapy, when compared with other skin renewal methods, has its own distinct advantages and limitations. The correct treatment choice is determined based on the patient's skin type, concern and expectations.

Criterion	Mesotherapy	Chemical Peeling	Laser	PRP	Skin Booster
Mechanism	Pharmacological	Chemical exfoliation	Photothermal	Biological	Hydration
Depth	Mesoderm	Epidermis–dermis	Variable	Dermis	Intradermal
Pain	Low–moderate	Low–moderate	Moderate–high	Low	Low
Social recovery	1–2 days	3–7 days	5–14 days	1 day	1 day
Sessions	4–6	3–6	2–4	3–4	3
Result duration	3–6 months	3–6 months	6–12 months	6–12 months	4–6 months
Summer application	Yes (carefully)	No	No	Yes	Yes

Combination Protocol with Chemical Peeling

The mesotherapy and chemical peeling combination is a synergistic treatment protocol based on first removing dead cells with peeling, then achieving more effective penetration of active substances with mesotherapy.

Combination Schedule:

1. Week 1: Superficial peeling (glycolic acid 20–35%)
2. Week 2: Mesotherapy (NCTF or vitamin cocktail)
3. Week 3: Home care + moisturisation
4. Week 4: Mid-depth peeling (TCA 15–25%)
5. Week 5: Mesotherapy (peptide + HA cocktail)
6. Week 6: Assessment and maintenance plan

This combination has been reported to produce 35–45% better results compared to mesotherapy alone.

Session Results and Clinical Evidence

Mesotherapy session results are assessed in clinical studies using objective measurement tools (VISIA, Cutometer, Corneometer), with treatment efficacy supported by scientific data.

Expected Improvements by Session:

Session	Hydration Improvement	Wrinkle Reduction	Radiance Increase	Elasticity Improvement
Session 1	15–20%	5–10%	10–15%	5–8%
Session 2	30–40%	15–20%	25–30%	12–18%
Session 3	50–60%	25–30%	40–50%	20–28%
Session 4	65–75%	30–40%	55–65%	28–35%
Session 5	75–85%	35–45%	65–75%	35–42%
Session 6	80–90%	40–50%	70–80%	40–48%

When IPL was combined with NCSH/TXA/VC mesotherapy, patient satisfaction was reported at 82.15%.

Mesotherapy Protocols by Skin Type

Mesotherapy protocol by skin type involves personalised treatment plans containing cocktail formulations and application parameters customised to the specific needs of each skin type (oily, dry, combination, sensitive, mature).

Skin Type	Cocktail Content	Depth	Session Interval	Special Attention
Oily	Zinc + Niacinamide + Salicylic acid + HA (low MW)	2–3 mm	2 weeks	Sebum regulation priority
Dry	HA (high MW) + B5 + Vitamin E + Ceramide precursors	1–2 mm	2–3 weeks	Barrier strengthening
Combination	Regional: T-zone oily cocktail, cheeks dry cocktail	1–3 mm	2 weeks	Regional differentiation
Sensitive	HA + Allantoin + Panthenol + low-concentration peptide	1–1.5 mm	3–4 weeks	Low dose, slow injection
Mature	NCTF + Peptides + Growth factors + Biostimulants	2–4 mm	2 weeks	Collagen stimulation focused
Acne-prone	Zinc + Vitamin C + Salicylic acid + Niacinamide	1–2 mm	2 weeks	Anti-inflammatory + sebum
Hyperpigmented	Glutathione + Vitamin C + Tranexamic acid + Kojic acid	1–2 mm	Weekly	Melanin inhibition

Mesotherapy and Combined Treatments

A combined treatment protocol is a multi-treatment plan aiming to create synergistic effects by applying mesotherapy together with other aesthetic procedures. With the right combination and timing, 30–50% better results can be achieved compared to a single treatment.

Combination	Order	Waiting Period	Expected Additional Benefit
Mesotherapy + PRP	Same session (PRP first)	—	40% increased collagen
Mesotherapy + Botox	Botox first	14 days	Line reduction + skin quality
Mesotherapy + Filler	Filler first	14–21 days	Volume + skin radiance
Mesotherapy + Laser	Laser first	21–28 days	Tissue renewal + nourishment
Mesotherapy + LED therapy	Same session (LED after)	—	Anti-inflammatory + healing
Mesotherapy + Peeling	Peeling first	7–14 days	Increased penetration

Home Care and Mesotherapy Support

Post-mesotherapy home care is a daily skin care protocol using products containing active substances that enhances the efficacy of clinical treatment and ensures the sustainability of results. Correct home care can extend mesotherapy results by 25–40%.

First 48 Hours After the Procedure:

1. Cleansing: Gentle cleansing with micellar water (do not use foaming products)
2. Moisturisation: HA-containing serum + light moisturiser
3. Sun protection: SPF 50+ (reapply every 2 hours)
4. To avoid: Make-up (first 12 hours), sauna, steam bath, swimming pool, intense exercise

Long-Term Home Care Protocol:

Step	Morning	Evening
Cleansing	Gentle gel cleanser	Double cleansing
Toner	HA + Niacinamide toner	AHA/BHA toner (on peeling days)
Serum	Vitamin C 15–20%	Retinol 0.3–1% (gradual increase)
Moisturiser	Light, HA-based	Ceramide + peptide-containing
Sun protection	SPF 50+ broad spectrum	—
Weekly	—	Enzyme peeling (1–2 times/week)

Seasonal Mesotherapy Planning

Seasonal mesotherapy planning is a dynamic treatment schedule in which cocktail ingredients and application frequency are adjusted according to the changing needs of the skin during different periods of the year.

Season	Focus	Cocktail Preference	Frequency	Points to Note
Spring	Summer preparation, pigmentation control	Vitamin C + Glutathione + HA	Every 2 weeks	Antioxidant loading
Summer	Hydration, UV protection	HA-dense + Antioxidant	Every 3–4 weeks	SPF compliance critical; do not combine with IPL
Autumn	Summer damage repair	NCTF + Peptide + TXA	Every 2 weeks	Suitable period for peeling combination
Winter	Deep renewal, intensive treatment	Meso-Xanthin + NCTF + biostimulant	Every 10–14 days	Most intensive treatments in this period

Amino Acids and Mesotherapy: Building Blocks

Amino acids are the building blocks of proteins, playing a critical role in collagen, elastin and keratin synthesis, and are fundamental components in mesotherapy cocktails supporting skin repair and renewal. NCTF formulation contains 23 different amino acids.

Key Amino Acids Used in Mesotherapy:

Amino Acid	Class	Function	Skin Effect
Proline	Non-essential	Primary material for collagen synthesis	Wrinkle reduction, tightening
Hydroxyproline	Modified	Collagen stabilisation	Structural integrity
Glycine	Non-essential	Collagen tripeptide structure	Skin repair
Lysine	Essential	Collagen cross-linking	Elasticity increase
Glutamine	Conditionally essential	Cell proliferation	Wound healing acceleration
Arginine	Conditionally essential	Nitric oxide synthesis, vasodilation	Increased blood flow, nourishment
Cysteine	Non-essential	Glutathione synthesis, antioxidant	Brightening, protection

In skin with amino acid deficiency, collagen synthesis decreases by 40–60%. Amino acids delivered directly to the dermis via mesotherapy provide 5–10 times higher bioavailability compared to topical application.

Contraindications and Side Effects

Mesotherapy contraindications cover the medical conditions and circumstances in which the procedure should not be applied — clinical criteria that must be assessed for patient safety.

Absolute Contraindications:

1. Pregnancy and breastfeeding
2. Active skin infection (herpes, bacterial)
3. Autoimmune diseases (active phase)
4. Bleeding disorders or anticoagulant therapy
5. Known allergy to mesotherapy components
6. Active cancer treatment
7. Uncontrolled diabetes (HbA1c > 9%)

Relative Contraindications:

• Keloid tendency
• Epilepsy
• Aspirin/NSAID use (should be stopped 7 days before)
• Active acne (severe)
• Areas with sunburn

Possible Side Effects:

Side Effect	Frequency	Duration	Management
Redness	90%+	2–24 hours	Cold compress
Oedema	40–60%	24–48 hours	Resolves spontaneously
Bruising	20–30%	3–7 days	Arnica cream
Papule at injection site	15–25%	24–72 hours	Absorbed spontaneously
Pain	30–50%	A few hours	Paracetamol
Infection	<1%	Variable	Antibiotic treatment
Allergic reaction	<0.5%	Variable	Emergency intervention

Hair Mesotherapy: Mesotherapy in Hair Loss Treatment

Hair mesotherapy is a mesotherapy application in which a cocktail containing biotin, dexpanthenol, zinc, minoxidil and growth factors is injected into the mesodermal layer of the scalp, aiming to reduce hair loss and improve hair quality. It offers an effective treatment option for androgenetic alopecia, telogen effluvium and general hair thinning.

Hair Mesotherapy Cocktail Content:

Component	Concentration	Function
Biotin (B7)	0.5–2 mg/ml	Keratin synthesis
Dexpanthenol (B5)	250–500 mg/ml	Hair root nourishment
Zinc	2–5 mg/ml	DHT inhibition
Minoxidil	2–5%	Vasodilation, hair growth cycle
Copper peptide (GHK-Cu)	0.1–0.5 mg/ml	Follicle stimulation
Hyaluronic acid	5–10 mg/ml	Scalp hydration

Hair Mesotherapy Session Plan:

Phase	Duration	Frequency	Sessions
Intensive course	First 2 months	Weekly	8 sessions
Consolidation	Months 3–4	Every 2 weeks	4 sessions
Maintenance	Month 5+	Monthly	Ongoing

Clinical studies have reported a 30–40% increase in hair thickness and a 50–60% reduction in active hair shedding following hair mesotherapy.

Mesotherapy Pricing Factors

Mesotherapy pricing has a multi-factorial structure that varies according to the type of cocktail used, the application area, number of sessions and clinic standards. We recommend contacting Virtuana Clinic for current pricing information.

Price Factor	Impact
Cocktail brand (NCTF vs generic)	30–50% difference
Application area (face vs scalp)	10–20% difference
Technique (manual vs mesogun)	15–25% difference
Session package (single vs package)	15–20% discount
Combined treatments	Package advantage

Frequently Asked Questions (FAQ)

1. What is skin mesotherapy and how does it work?

Skin mesotherapy is a skin renewal method in which cocktails of active substances containing vitamins, hyaluronic acid, peptides and minerals are injected with very fine needles (30–32 gauge) into the mesodermal layer of the skin (1–4 mm depth). Active substances reach the target tissue directly and can increase collagen synthesis by 165–256%.

2. Is mesotherapy painful?

Mesotherapy is generally minimally painful when combined with topical anaesthetic cream application. Very fine 30–32 gauge needles are used. The mesogun (gun) technique is less painful than the manual technique. More than 70% of patients describe the procedure as "uncomfortable but tolerable".

3. What is the difference between NCTF and Meso-Xanthin?

NCTF is a polycomponent formulation containing 53 active components and is effective in general skin rejuvenation. Meso-Xanthin F199 is fucoxanthin-based, targets cellular DNA repair and is particularly preferred in photo-ageing treatment. NCTF has a more comprehensive body of clinical study data.

4. What is the difference between mesotherapy and dermapen?

Mesotherapy delivers active substances directly into the skin via injection. Dermapen provides collagen induction through mechanical micro-needling and active substances are absorbed topically through micro-channels. Mesotherapy relies primarily on pharmacological effect, dermapen on mechanical effect.

5. How many sessions of mesotherapy are needed?

The initial course is generally planned as 4–6 sessions (every 2–4 weeks). Results become apparent from the 3rd session. 1 maintenance session every 4–8 weeks is recommended. The number of sessions may increase depending on skin type and the severity of the concern.

6. When can make-up be applied after mesotherapy?

Make-up should not be applied for at least 6–12 hours after the procedure. It is recommended to allow the skin to breathe for the first 24 hours. Mineral-based light make-up can be applied after 12 hours, and full make-up after 24 hours.

7. Can mesotherapy be done in summer?

Yes, mesotherapy can be applied in summer, but some precautions are required: SPF 50+ use is mandatory, sessions should preferably be scheduled in the evening, and brightening cocktails (glutathione, vitamin C) should be used more cautiously in summer months.

8. Does glutathione mesotherapy whiten the skin?

Glutathione mesotherapy brightens the skin tone by regulating melanin synthesis but does not whiten the skin beyond its natural tone. The effect manifests as reduction of hyperpigmentation, correction of uneven tone and an overall increase in skin radiance.

9. Are mesotherapy results permanent?

Mesotherapy results are not permanent. The effect lasts 3–6 months after the initial course. Results can be sustained with regular maintenance sessions. When maintenance treatment is stopped, the skin gradually returns to its pre-treatment state.

10. Which procedures can be combined with mesotherapy?

Mesotherapy can be combined with PRP (same session), botox (14 days apart), filler (14–21 days apart), laser (21–28 days apart), chemical peeling (7–14 days apart) and LED therapy (same session). Correct timing is critical for synergistic effect.

11. What is Glogau classification?

The Glogau classification is an assessment system that divides skin photo-ageing into 4 types: Type I (no wrinkles, age 20–30), Type II (wrinkles with movement, age 30–40), Type III (wrinkles at rest, age 40–55), Type IV (only wrinkles, age 55+). A different mesotherapy protocol is applied for each type.

12. Who cannot have mesotherapy?

Mesotherapy should not be applied to pregnant women, breastfeeding mothers, those with active skin infections, those with autoimmune disease in active phase, those with bleeding disorders, those allergic to mesotherapy components, and those receiving active cancer treatment.

13. Can mesotherapy also be applied to the hair?

Yes, hair mesotherapy is applied to the scalp using cocktails containing biotin, dexpanthenol, zinc and minoxidil. The goal is to reduce hair loss and improve hair quality. An initial course of 8–12 sessions (weekly) is generally applied.

14. Is mesotherapy and skin booster the same thing?

No. Mesotherapy targets general skin renewal with multi-component cocktails (vitamins, peptides, minerals). Skin booster is generally hyaluronic acid-based and provides only deep hydration. Mesotherapy is more comprehensive, skin booster more specific.

15. How is mesotherapy applied at Virtuana Clinic?

At Virtuana Clinic, Dr. Abdülmelik Dönmez assesses each patient's skin type and Glogau photo-ageing grade to create a personalised mesotherapy protocol. At our Izmit/Kocaeli centre, applications are performed with mesogun technology and premium cocktails (NCTF, peptide formulations). Please contact us for an appointment.